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Synergistic effects of ketamine and azole derivatives on Candida spp. resistance to fluconazole.
de Andrade Neto, João Batista; da Silva, Cecília Rocha; Barroso, Fátima Daiana; do Amaral Valente Sá, Lívia Gurgel; de Sousa Campos, Rosana; S Aires do Nascimento, Francisca Bruna; Sampaio, Letícia Serpa; da Silva, Anderson Ramos; da Silva, Lisandra Juvêncio; de Sá Carneiro, Igor; Queiroz, Helaine Almeida; de Mesquita, Jacó Ricarte Lima; Cavalcanti, Bruno Coelho; de Moraes, Manoel Odorico; Nobre Júnior, Hélio Vitoriano.
Afiliação
  • de Andrade Neto JB; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • da Silva CR; Christus University Center (UNICHRISTUS), Fortaleza, CE, 60160-230, Brazil.
  • Barroso FD; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • do Amaral Valente Sá LG; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • de Sousa Campos R; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • S Aires do Nascimento FB; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • Sampaio LS; Christus University Center (UNICHRISTUS), Fortaleza, CE, 60160-230, Brazil.
  • da Silva AR; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • da Silva LJ; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • de Sá Carneiro I; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • Queiroz HA; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • de Mesquita JRL; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • Cavalcanti BC; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, 60430-1160, Brazil.
  • de Moraes MO; St. Joseph Hospital for Infectious Diseases, Fortaleza, CE, Brazil.
  • Nobre Júnior HV; Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE, 60430-276, Brazil.
Future Microbiol ; 15: 177-188, 2020 02.
Article em En | MEDLINE | ID: mdl-32077323
The emergence of Candida spp. with resistance to antifungal molecules, mainly the azole class, is an increasing complication in hospitals around the globe. Aim: In the present research, we evaluated the synergistic effects of ketamine with two azole derivatives, itraconazole and fluconazole, on strains of Candida spp. to fluconazole. Materials & methods: The drug synergy was evaluated by quantifying the fractional inhibitory concentration index and by fluorescence microscopy and flow cytometry techniques. Results: Our achievements showed a synergistic effect between ketamine in addition to the two antifungal agents (fluconazole and itraconazole) against planktonic cells and biofilms of Candida spp. Conclusion: This combination promoted alteration of membrane integrity, generation of reactive oxygen species, damage to and DNA and externalization of phosphatidylserine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Fluconazol / Itraconazol / Ketamina / Antifúngicos Limite: Animals Idioma: En Revista: Future Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Fluconazol / Itraconazol / Ketamina / Antifúngicos Limite: Animals Idioma: En Revista: Future Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido