Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1&#945; axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.

Dong, Delu; Dong, Yuan; Fu, Jiaying; Lu, Shengyao; Yuan, Chunli; Xia, Meihui; Sun, Liankun

Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.

Dong, Delu; Dong, Yuan; Fu, Jiaying; Lu, Shengyao; Yuan, Chunli; Xia, Meihui; Sun, Liankun.

Afiliação

Dong D; Key Laboratory of Pathophysiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130033, Jilin Province, China.
Dong Y; College of Clinical Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Fu J; Key Laboratory of Pathophysiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130033, Jilin Province, China.
Lu S; Key Laboratory of Pathophysiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130033, Jilin Province, China.
Yuan C; Department of Obstetrics and Gynecology, First Hospital, Jilin University, 130021, Jilin Province, China.
Xia M; Department of Obstetrics and Gynecology, First Hospital, Jilin University, 130021, Jilin Province, China. Electronic address: milansummer@yeah.net.
Sun L; Key Laboratory of Pathophysiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130033, Jilin Province, China. Electronic address: sunlk@jlu.edu.cn.

Life Sci ; 255: 117846, 2020 Aug 15.

Article em En | MEDLINE | ID: mdl-32470451

Assuntos

Antineoplásicos/farmacologia; Compostos de Bifenilo/farmacologia; Nitrofenóis/farmacologia; Neoplasias Ovarianas/tratamento farmacológico; Estresse Oxidativo/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-bcl-2/antagonistas & inibidores; Sulfonamidas/farmacologia; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Feminino; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Neoplasias Ovarianas/patologia; Piperazinas/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Sirtuína 3/metabolismo

Palavras-chave

ABT737; Apoptosis; B-cell lymphoma 2; Glycolysis; Oxidative stress; Warburg effect

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Sulfonamidas / Compostos de Bifenilo / Estresse Oxidativo / Proteínas Proto-Oncogênicas c-bcl-2 / Antineoplásicos / Nitrofenóis Limite: Female / Humans Idioma: En Revista: Life Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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