Your browser doesn't support javascript.
loading
Dietary Plant Protein and Mortality Among Patients Receiving Maintenance Hemodialysis: A Cohort Study.
He, Yanhuan; Lu, Yongxin; Yang, Shenglin; Li, Yumin; Yang, Yaya; Chen, Junzhi; Huang, Yan; Lin, Zizhen; Li, Youbao; Kong, Yaozhong; Zhao, Yanhong; Wan, Qijun; Wang, Qi; Huang, Sheng; Liu, Yan; Liu, Aiqun; Liu, Fanna; Hou, Fan Fan; Qin, Xianhui; Liang, Min.
Afiliação
  • He Y; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
  • Lu Y; People's Hospital of Yuxi City, Yuxi, People's Republic of China.
  • Yang S; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
  • Li Y; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
  • Yang Y; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
  • Chen J; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
  • Huang Y; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
  • Lin Z; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
  • Li Y; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
  • Kong Y; First People's Hospital of Foshan, Foshan, People's Republic of China.
  • Zhao Y; People's Hospital of Yuxi City, Yuxi, People's Republic of China.
  • Wan Q; Second People's Hospital of Shenzhen, Shenzhen, People's Republic of China.
  • Wang Q; Huadu District People's Hospital of Guangzhou, Guangzhou, People's Republic of China.
  • Huang S; Nanhai District People's Hospital of Foshan, Foshan, People's Republic of China.
  • Liu Y; Nephrology Department, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, People's Republic of China.
  • Liu A; Third Affiliated Hospital of Southern Medical University, Guangzhou, People's Republic of China.
  • Liu F; Guangzhou Overseas Chinese Hospital, Guangzhou, People's Republic of China.
  • Hou FF; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
  • Qin X; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China. Electronic address: pharmaqin@126.com.
  • Liang M; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China. Electronic address: nfyylm@163.com.
Am J Kidney Dis ; 78(5): 649-657.e1, 2021 11.
Article em En | MEDLINE | ID: mdl-34052356
RATIONALE & OBJECTIVE: Although greater dietary intake of protein has been associated with beneficial health effects among patients receiving maintenance hemodialysis (MHD), the effects of plant protein intake are less certain. We studied the association of the proportion of protein intake derived from plant sources with the risk of mortality among patients receiving MHD and explored factors that may modify these associations. STUDY DESIGN: Prospective observational cohort study. SETTING & PARTICIPANTS: 1,119 Chinese hemodialysis patients aged over 18 years receiving MHD in 2014-2015. PREDICTORS: The proportion of plant protein intake to total protein intake. OUTCOMES: All-cause mortality and cardiovascular disease (CVD) mortality. ANALYTICAL APPROACH: Segmented regression models were fit to examine the association of plant protein intake proportion with the risk of all-cause mortality and CVD mortality. Multivariable-adjusted Cox proportional and cause-specific hazards models were used to estimate the hazard ratios (HR) and 95% CI for these outcomes. RESULTS: The means of plant protein intake normalized to ideal body weight and plant protein intake proportion were 0.6±0.2 (SD) g/kg per day and 0.538±0.134, respectively. During a median follow-up period of 28.0 months, 249 deaths occurred, with 146 of these deaths resulting from CVD. Overall, there was a U-shaped association between plant protein intake proportion and the risk of all-cause mortality, with an inflection point at 45%. Among patients with a plant protein intake proportion<45%, there was a 17% lower rate of mortality with each 5% greater plant protein intake proportion (HR, 0.83 [95% CI, 0.73-0.96]). Among patients with plant protein intake proportion≥45%, there was a 9% greater rate of mortality with each 5% greater plant protein intake proportion. A similar U-shaped association was observed for CVD mortality, with an inflection point at 44%. LIMITATIONS: Observational study, potential unmeasured confounding. CONCLUSIONS: There was a U-shaped association between plant protein intake proportion and the risk of all-cause and cardiovascular mortality in MHD patients. If confirmed, these findings suggest a potential avenue to improve outcomes in this patient population.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Vegetais Comestíveis / Doenças Cardiovasculares Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: En Revista: Am J Kidney Dis Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Vegetais Comestíveis / Doenças Cardiovasculares Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: En Revista: Am J Kidney Dis Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos