HPIP protooncogene differentially regulates metabolic adaptation and cell fate in breast cancer cells under glucose stress via AMPK and RNF2 dependent pathways.

Penugurti, Vasudevarao; Khumukcham, Saratchandra Singh; Padala, Chiranjeevi; Dwivedi, Anju; Kamireddy, Karthik Reddy; Mukta, Srinivasulu; Bhopal, Triveni; Manavathi, Bramanandam

Penugurti, Vasudevarao; Khumukcham, Saratchandra Singh; Padala, Chiranjeevi; Dwivedi, Anju; Kamireddy, Karthik Reddy; Mukta, Srinivasulu; Bhopal, Triveni; Manavathi, Bramanandam.

Afiliação

Penugurti V; Molecular and Cellular Oncology Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, Telangana, India.
Khumukcham SS; Molecular and Cellular Oncology Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, Telangana, India.
Padala C; Molecular and Cellular Oncology Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, Telangana, India.
Dwivedi A; Molecular and Cellular Oncology Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, Telangana, India.
Kamireddy KR; Molecular and Cellular Biology Laboratory, Baylor College of Medicine, Houston, TX, United States.
Mukta S; MNJ Institute of Oncology and Regional Cancer Center, Hyderabad, 500004, Telangana, India.
Bhopal T; MNJ Institute of Oncology and Regional Cancer Center, Hyderabad, 500004, Telangana, India.
Manavathi B; Molecular and Cellular Oncology Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, Telangana, India. Electronic address: manavathibsl@uohyd.ac.in.

Cancer Lett ; 518: 243-255, 2021 10 10.

Article em En | MEDLINE | ID: mdl-34302919

Assuntos

Proteínas Quinases Ativadas por AMP/metabolismo; Neoplasias da Mama/metabolismo; Glucose/metabolismo; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Complexo Repressor Polycomb 1/metabolismo; Adaptação Fisiológica/fisiologia; Animais; Apoptose/fisiologia; Diferenciação Celular/fisiologia; Linhagem Celular; Linhagem Celular Tumoral; Feminino; Glutaminase/metabolismo; Glutamina/metabolismo; Células HEK293; Humanos; Células MCF-7; Camundongos; Camundongos Nus; Antígenos de Histocompatibilidade Menor; Estresse Fisiológico/fisiologia; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

AMPK; Apoptosis; Cell survival; FOXO3a; Glutaminolysis; HPIP; MYC

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Peptídeos e Proteínas de Sinalização Intracelular / Proteínas Quinases Ativadas por AMP / Complexo Repressor Polycomb 1 / Glucose Limite: Animals / Female / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia País de publicação: Irlanda

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