The underestimated contribution of the solvent to the phase behavior of highly drug loaded amorphous solid dispersions.

Dedroog, Sien; Boel, Eline; Kindts, Célestine; Appeltans, Bernard; Van den Mooter, Guy

Dedroog, Sien; Boel, Eline; Kindts, Célestine; Appeltans, Bernard; Van den Mooter, Guy.

Afiliação

Dedroog S; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.
Boel E; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.
Kindts C; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.
Appeltans B; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.
Van den Mooter G; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium. Electronic address: Guy.vandenmooter@kuleuven.be.

Int J Pharm ; 609: 121201, 2021 Nov 20.

Article em En | MEDLINE | ID: mdl-34673165

Assuntos

Química Farmacêutica; Preparações Farmacêuticas; Composição de Medicamentos; Solubilidade; Solventes

Palavras-chave

Amorphous solid dispersions; Film casting - Solvent; Kinetic stabilization; Kinetic trapping; Spray drying

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Química Farmacêutica Idioma: En Revista: Int J Pharm Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Bélgica País de publicação: Holanda

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