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Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification.
Carbone, Daniela; Vestuto, Vincenzo; Ferraro, Maria Rosalia; Ciaglia, Tania; Pecoraro, Camilla; Sommella, Eduardo; Cascioferro, Stella; Salviati, Emanuela; Novi, Sara; Tecce, Mario Felice; Amodio, Giuseppina; Iraci, Nunzio; Cirrincione, Girolamo; Campiglia, Pietro; Diana, Patrizia; Bertamino, Alessia; Parrino, Barbara; Ostacolo, Carmine.
Afiliação
  • Carbone D; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Vestuto V; Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084, Fisciano, SA, Italy.
  • Ferraro MR; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Ciaglia T; Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084, Fisciano, SA, Italy.
  • Pecoraro C; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Sommella E; Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084, Fisciano, SA, Italy.
  • Cascioferro S; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Salviati E; Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084, Fisciano, SA, Italy.
  • Novi S; Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084, Fisciano, SA, Italy.
  • Tecce MF; Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084, Fisciano, SA, Italy.
  • Amodio G; Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana"/DIPMED, Via S. Allende, 84081, Baronissi, SA, Italy.
  • Iraci N; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166, Messina, Italy.
  • Cirrincione G; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Campiglia P; Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084, Fisciano, SA, Italy.
  • Diana P; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Bertamino A; Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084, Fisciano, SA, Italy.
  • Parrino B; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy. Electronic address: barbara.parrino@unipa.it.
  • Ostacolo C; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131, Naples, Italy. Electronic address: ostacolo@unina.it.
Eur J Med Chem ; 234: 114233, 2022 Apr 15.
Article em En | MEDLINE | ID: mdl-35286926
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas / Glutaminase Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas / Glutaminase Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália