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Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures.
Gonçalves da Costa Sousa, Mauricio; Conceição de Almeida, Gabriela; Martins Mota, Danilo César; Andrade da Costa, Rosiane; Dias, Simoni Campos; Limberger, Samuel Nunes; Ko, Frank; Lin, Li Ting; Haney, Evan F; Etayash, Hashem; Baquir, Beverlie; Trimble, Michael J; Shen, Ya; Su, Zheng; Haapasalo, Markus; Pletzer, Daniel; Chaves de Souza, Letícia; Schuindt Teixeira, Gláucia; Silva, Renato M; Hancock, Robert E W; Franco, Octavio Luiz; Berto Rezende, Taia Maria.
Afiliação
  • Gonçalves da Costa Sousa M; Post-Graduation Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
  • Conceição de Almeida G; Dentistry Course, Catholic University of Brasília, Brasília, Brazil.
  • Martins Mota DC; Post-Graduation Program in Health Sciences, University of Brasília, Brazil.
  • Andrade da Costa R; Post-Graduation Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
  • Dias SC; Post-Graduation Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil.
  • Limberger SN; Animal Biology Department, Campus Darcy Ribeiro, Universidade de Brasília, Brazil.
  • Ko F; LIMA, Chemistry Institute, University of Brasília-UNB, Brasília, Brazil.
  • Lin LT; Department of Materials Engineering, Faculty of Applied Science, University of British Columbia, Vancouver, Canada.
  • Haney EF; Department of Materials Engineering, Faculty of Applied Science, University of British Columbia, Vancouver, Canada.
  • Etayash H; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
  • Baquir B; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
  • Trimble MJ; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
  • Shen Y; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
  • Su Z; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
  • Haapasalo M; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
  • Pletzer D; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
  • Chaves de Souza L; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
  • Schuindt Teixeira G; Department of Endodontics, School of Dentistry, University of Texas Health Science Center at Houston, Houston, USA.
  • Silva RM; Department of Endodontics, School of Dentistry, University of Texas Health Science Center at Houston, Houston, USA.
  • Hancock REW; Department of Prosthesis, Faculty of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Franco OL; Department of Endodontics, School of Dentistry, University of Texas Health Science Center at Houston, Houston, USA.
  • Berto Rezende TM; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Bioact Mater ; 16: 173-186, 2022 Oct.
Article em En | MEDLINE | ID: mdl-35386316
Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis, Staphylococcus aureus and a multispecies oral biofilm, besides anti-inflammatory activities. The in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation, when compared to empty teeth fragments. Thus, we designed a strong antimicrobial, immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Bioact Mater Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Bioact Mater Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: China