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Porous thermosensitive coating with water-locking ability for enhanced osteogenic and antibacterial abilities.
Hao, Xueqing; Zhou, Jielong; Xie, Juning; Zou, Xianrui; Li, Baoe; Liang, Chunyong; Zhang, Yu; Peng, Feng; Wang, Donghui.
Afiliação
  • Hao X; School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300130, China.
  • Zhou J; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, China.
  • Xie J; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, China.
  • Zou X; School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300130, China.
  • Li B; School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300130, China.
  • Liang C; School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300130, China.
  • Zhang Y; Fujian Provincial Key Laboratory for Advanced Micro-nano Photonics Technology and Devices, Research Center for Photonics Technology, Quanzhou Normal University, China.
  • Peng F; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, China.
  • Wang D; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, China.
Mater Today Bio ; 14: 100285, 2022 Mar.
Article em En | MEDLINE | ID: mdl-35647512
Preferable antibacterial property and osteogenesis are the permanent pursuit for metallic implants. However, it is difficult to satisfy both the properties. In fact, implants may be contaminated with bacteria during storage and surgery, leading to inflammation. Therefore, the antibacterial property of biomaterial surfaces is required not only in the human environment but also at room temperature. In this study, porous structures loaded with a thermosensitive poly (N-isopropylacrylamide) (PNIPAM) hydrogel on a nitinol (NiTi) substrate were constructed. When the temperature is 25 â€‹°C, almost all bacteria cannot adhere to the sample surface due to the abundant hydration layer of the PNIPAM hydrogel. Meanwhile, when the temperature is 37 â€‹°C, the structure of the PNIPAM hydrogel collapses and the hydration layer disappears due to the temperature change. However, the porous structures lock water in the pores, which results in a high-hydration-rate sample surface. This surface has few bacterial adhesion sites; nevertheless, the adhesion of larger cells to the surface is not impeded by the porous structure. In addition, the PNIPAM hydrogel is soft and biocompatible, so the sample can have better cell adhesion and proliferation than a bare NiTi alloy. Based on these results, it can be concluded that the porous NiTi sample loaded with the thermosensitive PNIPAM hydrogel has the antibacterial property before implantation and the dual function of inhibiting bacterial adhesion and promoting cell adhesion and proliferation after implantation, which shows promising applications in the biomedical field such as orthopedic implantation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mater Today Bio Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mater Today Bio Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido