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Evaluating the effect of curcumin on the metacestode of Taenia crassiceps.
Martínez-González, José de Jesús; Ríos-Morales, Sandra Lizeth; Guevara-Flores, Alberto; Ramos-Godinez, María Del Pilar; López-Saavedra, Alejandro; Rendón, Juan Luis; Del Arenal Mena, Irene Patricia.
Afiliação
  • Martínez-González JJ; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, 04510, Mexico City, Mexico.
  • Ríos-Morales SL; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, 04510, Mexico City, Mexico.
  • Guevara-Flores A; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, 04510, Mexico City, Mexico.
  • Ramos-Godinez MDP; Unidad de Aplicaciones Avanzadas en Microscopía, Instituto Nacional de Cancerología, Red de Apoyo a la Investigación (RAI), 14080, Mexico City, Mexico.
  • López-Saavedra A; Unidad de Aplicaciones Avanzadas en Microscopía, Instituto Nacional de Cancerología, Red de Apoyo a la Investigación (RAI), 14080, Mexico City, Mexico.
  • Rendón JL; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, 04510, Mexico City, Mexico.
  • Del Arenal Mena IP; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, 04510, Mexico City, Mexico. Electronic address: darenal@bq.unam.mx.
Exp Parasitol ; 239: 108319, 2022 Aug.
Article em En | MEDLINE | ID: mdl-35777452
Curcumin, a curcuminoid present in the rhizome of the plant Curcuma longa has multiple pharmacological effects including anticarcinogenic and anti-inflammatory properties. This work evaluates the anthelmintic effect of the curcumin molecule (98% pure) on Taenia crassiceps cysticerci viability in vitro. Cysticerci incubated in the presence of increasing concentrations of curcumin showed a dose-dependent mortality correlated with a significant increase in the production of reactive oxygen species and a partial inhibition of thioredoxin-glutathione reductase, the only disulfide reductase present in these parasites. At 500 µM curcumin, a 100% of cysticerci lethality was obtained after 2 h of treatment. These results suggest the curcumin-induced oxidative stress could be in the origin of the anthelminthic effect of curcumin. Mice with cysticerci were injected intraperitoneally with 20, 40, or 60 mM curcumin daily for 30 days. A decrease in the burden of cysticerci (46%) was observed with a 60 mM dose of curcumin, supporting this compound as a potential anthelmintic drug.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Taenia / Cisticercose / Curcumina / Anti-Helmínticos Limite: Animals Idioma: En Revista: Exp Parasitol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Taenia / Cisticercose / Curcumina / Anti-Helmínticos Limite: Animals Idioma: En Revista: Exp Parasitol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos