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Tetracyclines in pasteurized milk commercialized in São Paulo, Brazil: occurrence and dietary risk assessment based on single and combined exposure with polyether ionophores.
Spisso, Bernardete Ferraz; Pereira, Mararlene Ulberg; Ferreira, Rosana Gomes; Silva, Felipe Rodrigues Nogueira; Arisseto-Bragotto, Adriana Pavesi.
Afiliação
  • Spisso BF; Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz (INCQS/FIOCRUZ), Rio de Janeiro, Brazil.
  • Pereira MU; Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz (INCQS/FIOCRUZ), Rio de Janeiro, Brazil.
  • Ferreira RG; Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz (INCQS/FIOCRUZ), Rio de Janeiro, Brazil.
  • Silva FRN; School of Food Engineering, University of Campinas - UNICAMP, Campinas, Brazil.
  • Arisseto-Bragotto AP; School of Food Engineering, University of Campinas - UNICAMP, Campinas, Brazil.
Food Addit Contam Part B Surveill ; 15(4): 254-265, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35861122
Tetracyclines and polyether ionophores are veterinary drugs frequently used in animals reared for food production. Despite the benefits, residues can be harmful for human health if levels are higher than those considered safe. The aim of this study was to evaluate, by LC-MS/MS, tetracyclines residues in pasteurised milk samples marketed in São Paulo state, Brazil and estimate the exposure of the adult/adolescent/children population. Within the eight antibiotics monitored two were detected, tetracycline and 4-epitetracycline, found in 22.5% and 12.5% of the samples, respectively. Since the same samples had been previously tested for polyether ionophore residues, risk assessment based on dietary exposure to tetracyclines when considered individually and in combination with the ionophores was performed. The daily intakes were below the acceptable daily intake (ADI) for tetracycline. Considering the levels of monensin reported in a previous study, the combined exposure with tetracycline and 4-epi-tetracycline also indicated low potential health concerns.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetraciclinas / Resíduos de Drogas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Animals / Child / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Food Addit Contam Part B Surveill Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetraciclinas / Resíduos de Drogas Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Animals / Child / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Food Addit Contam Part B Surveill Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido