Antitumor activity of a pexidartinib bioisostere inhibiting CSF1 production and CSF1R kinase activity in human hepatocellular carcinoma.

Awasthi, Bhuwan Prasad; Guragain, Diwakar; Chaudhary, Prakash; Jee, Jun-Goo; Kim, Jung-Ae; Jeong, Byeong-Seon

Awasthi, Bhuwan Prasad; Guragain, Diwakar; Chaudhary, Prakash; Jee, Jun-Goo; Kim, Jung-Ae; Jeong, Byeong-Seon.

Afiliação

Awasthi BP; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Guragain D; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Chaudhary P; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Jee JG; College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea.
Kim JA; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea. Electronic address: jakim@yu.ac.kr.
Jeong BS; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea. Electronic address: jeongb@ynu.ac.kr.

Chem Biol Interact ; 369: 110255, 2023 Jan 05.

Article em En | MEDLINE | ID: mdl-36368339

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; Humanos; Fator Estimulador de Colônias de Macrófagos/genética; Fator Estimulador de Colônias de Macrófagos/metabolismo; Receptor de Fator Estimulador de Colônias de Macrófagos/metabolismo; Carcinoma Hepatocelular/tratamento farmacológico; Neoplasias Hepáticas/tratamento farmacológico

Palavras-chave

Anti-Tumor activity; Bioisosterism; Cancer-macrophage co-culture; Colony-stimulating factor-1 receptor; Tumor-associated macrophages

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Chem Biol Interact Ano de publicação: 2023 Tipo de documento: Article País de publicação: Irlanda

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