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The deep cerebellar nuclei to striatum disynaptic connection contributes to skilled forelimb movement.
Contreras-López, Rubén; Alatriste-León, Hector; Díaz-Hernández, Edgar; Ramírez-Jarquín, Josué O; Tecuapetla, Fatuel.
Afiliação
  • Contreras-López R; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, Mexico.
  • Alatriste-León H; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, Mexico.
  • Díaz-Hernández E; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, Mexico.
  • Ramírez-Jarquín JO; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, Mexico.
  • Tecuapetla F; Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, Ciudad de México 04510, Mexico. Electronic address: fatuel@ifc.unam.mx.
Cell Rep ; 42(1): 112000, 2023 01 31.
Article em En | MEDLINE | ID: mdl-36656714
Cerebellar-thalamo-striatal synaptic communication has been implicated in a wide range of behaviors, including goal-directed actions, and is altered in cerebellar dystonia. However, its detailed connectivity through the thalamus and its contribution to the execution of forelimb movements is unclear. Here, we use trans-synaptic and retrograde tracing, ex vivo slice recordings, and optogenetic inhibitions during the execution of unidirectional or sequential joystick displacements to demonstrate that the deep cerebellar nuclei (DCN) influence the dorsal striatum with a very high probability. We show that this mainly occurs through the centrolateral (CL), parafascicular (PF), and ventrolateral (VL) nuclei of the thalamus, observing that the DCN→VL and DCN→CL pathways contribute to the execution of unidirectional forelimb displacements while the DCN→PF and DCN→thalamo→striatal pathways contribute to the appropriate execution of forelimb reaching and sequential displacements. These findings highlight specific contributions of the different cerebellar-thalamo-striatal paths to the control of skilled forelimb movement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleos Cerebelares / Corpo Estriado Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleos Cerebelares / Corpo Estriado Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos