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Influence of ambroxol on lung tissue penetration of amoxicillin.
Spátola, J; Poderoso, J J; Wiemeyer, J C; Fernández, M; Guerreiro, R B; Corazza, C.
Afiliação
  • Spátola J; Instituto Roffo, University of Buenos Aires, Argentina.
Arzneimittelforschung ; 37(8): 965-6, 1987 Aug.
Article em En | MEDLINE | ID: mdl-3675694
Lung amoxicillin levels were assessed in tissue obtained from 16 patients who underwent lung resection due to different pulmonary diseases. In this double-blind placebo controlled study patients were allocated to two groups in randomized order; one group received amoxicillin 1000 mg t.i.d. (n = 8) and the other amoxicillin 1000 mg + ambroxol 60 mg t.i.d. (n = 8). A trend towards higher antibiotic lung tissue levels was observed in patients who received the antibiotic together with the mucolytic agent. The ratio pulmonary tissue/serum amoxicillin levels reached a significant difference being higher in the amoxicillin plus ambroxol group than in the other one (0.411 +/- 0.04 vs 0.672 +/- 0.07; p less than 0.01), even if the amoxicillin plasma levels were lower. A possible effect of ambroxol on lung tissue penetration of amoxicillin is suggested and discussed.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bromoexina / Ambroxol / Amoxicilina / Pulmão Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arzneimittelforschung Ano de publicação: 1987 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bromoexina / Ambroxol / Amoxicilina / Pulmão Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arzneimittelforschung Ano de publicação: 1987 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha