Downregulation of BRD4 attenuates high glucose-induced damage of trophoblast cells by inhibiting activation of AKT/mTOR pathway.

Chai, Ou; Tang, Na; Guo, Ruimeng; Cui, Dongqing; Hou, Zhimin

Chai, Ou; Tang, Na; Guo, Ruimeng; Cui, Dongqing; Hou, Zhimin.

Afiliação

Chai O; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China; Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin 300134, China. Electronic address: chaiou2099@163
Tang N; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China; Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin 300134, China.
Guo R; Gynecology Department, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Cui D; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China; Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin 300134, China.
Hou Z; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China; Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin 300134, China. Electronic address: houzhimin3068@

Reprod Biol ; 23(2): 100751, 2023 Jun.

Article em En | MEDLINE | ID: mdl-36871542

Assuntos

Diabetes Gestacional; Pré-Eclâmpsia; Gravidez; Feminino; Humanos; Trofoblastos/metabolismo; Regulação para Baixo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Linhagem Celular; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo; Diabetes Gestacional/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Glucose/farmacologia; Glucose/metabolismo; Movimento Celular/fisiologia; Proliferação de Células; Pré-Eclâmpsia/metabolismo; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo

Palavras-chave

AKT/mTOR pathway; Bromodomain protein 4; Gestational diabetes mellitus; High glucose; Trophoblast cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Diabetes Gestacional Limite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Biol Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Polônia

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