Your browser doesn't support javascript.
loading
CLINICAL AND PATHOLOGICAL CHARACTERIZATION OF HEPATIC LYMPHOMAS: A RETROSPECTIVE SINGLE-CENTER STUDY.
Dias, Emanuel; Marques, Margarida; Gonçalves, Raquel; Cardoso, Pedro; Macedo, Guilherme.
Afiliação
  • Dias E; Gastroenterology Department, University Hospital Center of São João, Porto, Portugal.
  • Marques M; Gastroenterology Department, University Hospital Center of São João, Porto, Portugal.
  • Gonçalves R; Gastroenterology Department, University Hospital Center of São João, Porto, Portugal.
  • Cardoso P; Gastroenterology Department, University Hospital Center of São João, Porto, Portugal.
  • Macedo G; Gastroenterology Department, University Hospital Center of São João, Porto, Portugal.
Arq Gastroenterol ; 60(1): 65-73, 2023.
Article em En | MEDLINE | ID: mdl-37194782
BACKGROUND: The incidence of hepatic lymphoma has been increasing recently and diagnosis can be challenging as clinical presentation and radiological findings are usually variable and non-specific. OBJECTIVE: The aims of this study were to describe their main clinical, pathological and imaging characteristics and identify poor prognostic factors. METHODS: A retrospective study that included all patients with histological diagnosis of liver lymphoma over a 10-year period at our center was performed. RESULTS: A total of 36 patients were identified, with mean age of 56.6 years and male predominance (58%). There were three patients with primary liver lymphoma (8.3%) and 33 with secondary liver lymphoma (91.7%). The most common histological type was diffuse large B-cell lymphoma (33.3%). The most common clinical manifestations included fever, lymphadenopathy, weight loss, night sweats and abdominal discomfort; three patients (11.1%) were asymptomatic. Computed tomography scan revealed heterogenous radiological patterns including a single nodule (26.5%), multiple nodules (41.2%) or diffuse infiltration (32.4%). The mortality rate during follow-up was 55.6%. Higher levels of C-reactive protein (P=0.031) and absence of treatment response (P<0.001) were significantly associated with higher mortality. CONCLUSION: Hepatic lymphoma is a rare disease that may involve liver as part of a systemic disease or, less commonly, be confined to this organ. Clinical presentation and radiological findings are often variable and non-specific. It is associated with high mortality and poor prognostic factors include higher levels of C-reactive protein and absence of response to treatment.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Linfoma Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Portugal País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Linfoma Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Portugal País de publicação: Brasil