Standardized measurement of mid-surface shift of brain based on deep Hough transform.

The measurement of mid-surface shift (MSS), the geometric displacement between the actual mid-surface and the ideal midsagittal plane (iMSP), is of great significance for accurate diagnosis, treatment and prognosis of patients with intracranial hemorrhage (ICH). Most previous studies are subject to inherent inaccuracy on account of calculating midline shift (MLS) based on 2D slices and ignoring pathological conditions. In this study, we propose a novel standardized measurement model to quantify the distance and the overall volume of mid-surface shift (MSS-D, MSS-V). Our work has four highlights. First, we develop an end-to-end network architecture with multiple sub-tasks including the actual mid-surface segmentation, hematoma segmentation and iMSP detection, which significantly improves the efficiency and accuracy of MSS measurement by taking advantage of the common properties among tasks. Second, an efficient iMSP detection scheme is proposed based on the differentiable deep Hough transform (DHT), which converts and simplifies the plane detection problem in the image space into a keypoint detection problem in the Hough space. Third, we devise a sparse DHT strategy and a weighted least square (WLS) method to increase the sparsity of features, improving inference speed and greatly reducing computation cost. Fourth, we design a joint loss function to comprehensively consider the correlation of features between multi-tasks and multi-domains. Extensive validation on our large in-house dataset (519 patients) and the public CQ500 dataset (491 patients), demonstrates the superiority of our method over the state-of-the-art methods.