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SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the Loss of Primary Cilia.
Li, Lianshun; Zhao, Huiming; Li, Zhengyang; Shi, Wengui; Jiao, Zuoyi.
Afiliação
  • Li L; The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
  • Zhao H; The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
  • Li Z; The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
  • Shi W; Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou, China.
  • Jiao Z; The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
DNA Cell Biol ; 43(3): 141-151, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38215233
ABSTRACT
Primary cilia are microtubule-based organelles that mediate various biological processes. Pancreatic cells are typically ciliated; however, the role of primary cilia in acute pancreatitis (AP) is largely unknown. Here, we report that the loss of primary cilia, mediated by SHCBP1 (SHC1 binding protein), exerted a provocative effect on AP. Primary cilia are extensively lost in inflamed pancreatic cells in vitro and in mouse tissues with AP in vivo. Abrogation of primary cilia aggravated lipopolysaccharide (LPS)-induced inflammation in pancreatic cells. Mechanistically, AP induced the overexpression of SHCBP1 mitotic factor, which is localized to the base of primary cilia. SHCBP1 deficiency relieved LPS- and cerulein-induced pancreatitis by preventing the loss of primary cilia in vitro and in vivo. Collectively, we reveal that inflammation-induced loss of primary cilia aggravates AP. Furthermore, abrogating SHCBP1 to prevent primary cilia loss is an efficient strategy to combat AP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pancreatite Limite: Animals Idioma: En Revista: DNA Cell Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pancreatite Limite: Animals Idioma: En Revista: DNA Cell Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos