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The Combination of circEPSTI1 and MIF Offers Diagnostic Value for Endometrial Cancer.
Cui, Zhili; Zhou, Liyuan; An, Xin; Liu, Wenli; Li, Jingxia; Zhang, Yueping; Zhang, Wei.
Afiliação
  • Cui Z; Department of Gynecology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, 056002, People's Republic of China.
  • Zhou L; Department of Gynecology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, 056002, People's Republic of China.
  • An X; Department of Pathology, Handan First Hospital, Handan, Hebei, 056000, People's Republic of China.
  • Liu W; Department of Gynecology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, 056002, People's Republic of China.
  • Li J; Department of Gynecology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, 056002, People's Republic of China.
  • Zhang Y; Shexian Maternal and Child Health Hospital, Shexian, Hebei, 056004, People's Republic of China.
  • Zhang W; Department of Gynecology, Handan Traditional Chinese Medicine Hospital, Handan, Hebei, 056001, People's Republic of China.
Int J Gen Med ; 17: 1395-1403, 2024.
Article em En | MEDLINE | ID: mdl-38617055
ABSTRACT

Background:

Circular RNAs (circRNAs) exhibit unique patterns of expression and high levels of stability in patient plasma samples such that they represent ideal non-invasive biomarkers that can be leveraged to detect a wide array of diseases including endometrial cancer (EC). This study was designed to identify circRNAs with potential diagnostic utility in serum samples from EC patients while also evaluating the utility of macrophage migration inhibitory factor (MIF) as a biomarker when screening for this form of cancer in the clinic.

Methods:

Levels of circEPSTI1 and MIF were assessed in the plasma of EC patients and healthy subjects (n=186 each) through qPCR and ELISAs. The diagnostic utility of these biomarkers was assessed with receiver operating characteristic curve (ROC) analyses.

Results:

Relative to healthy subjects, EC patient serum contained significantly elevated circEPSTI1 and MIF. An association was noted between circEPSTI1 expression in stages, histologic grade, and residual tumor. ROC curves confirmed that serum circEPSTI1 levels distinguished between controls and patients with EC with an Area of 0.835 and serum MIF levels distinguished between controls and patients with EC with an Area of 0.6646. When instead diagnosing patients based on the combination of MIF and circEPSTI1, the Area further rose to 0.8604.

Conclusion:

Assessing the combination of circEPSTI1 and MIF may be a viable approach to reliably diagnosing EC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Gen Med Ano de publicação: 2024 Tipo de documento: Article País de publicação: Nova Zelândia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Gen Med Ano de publicação: 2024 Tipo de documento: Article País de publicação: Nova Zelândia