[Quantification of Ki-67 in PitNET (pituitary neuroendocrine tumors)/adenomas]. / Quantifizierung von Ki-67 in PitNET ("pituitary neuroendocrine tumors")/Adenomen.
Pathologie (Heidelb)
; 45(5): 339-343, 2024 Sep.
Article
em De
| MEDLINE
| ID: mdl-38992316
ABSTRACT
This study is the first to compare the determination of the Ki-67 index in pituitary neuroendocrine tumors (PitNET)/pituitary adenomas by pathologists with a computerized method (Cognition MasterSuite from VMScope, Berlin, Germany). PitNET/pituitary adenomas often show a low proliferation index. Observer variability is high, especially when estimating in this low percentage range. A more reliable determination would be possible using the four-eyes principle, but this cannot be realized continuously; thus, digital image analysis is a promising solution. In the study, there was clear agreement between the Ki-67 estimate by two experienced pathologists and the determination with the aid of digital image analysis. The digital image analysis system is excellent for determining the proliferation rate of PitNET/pituitary adenomas and can therefore be used to determine the "third" and "fourth eye".
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hipofisárias
/
Adenoma
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Tumores Neuroendócrinos
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Antígeno Ki-67
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
De
Revista:
Pathologie (Heidelb)
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Alemanha