Available Strategies for Improving the Biosynthesis of Methionine: A Review.
J Agric Food Chem
; 72(31): 17166-17175, 2024 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-39074311
ABSTRACT
Methionine is the only nonpolar α-amino acid containing sulfur among the eight essential amino acids and is closely related to the metabolism of sulfur-containing compounds in the human body. Widely used in feed, medicine, food, and other fields, the market demand is increasing annually. However, low productivity and high cost largely limit the industrial production of methionine, and many novel production methods still have their own disadvantages. In this paper, the available methods for synthesizing methionine are reviewed and discussed. The latest strategies for improving methionine production are further introduced, including culture medium optimization, mutation technology, expression of key genes in the metabolic pathway, knockout and recombination, as well as the engineering of membrane transporters, the fermentation-enzymatic coupling route, and innovation of CO2 biotransformation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Engenharia Metabólica
/
Metionina
Limite:
Humans
Idioma:
En
Revista:
J Agric Food Chem
/
J. agric. Food chem
/
Journal of agricultural and food chemistry
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Estados Unidos