Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice.
J Clin Invest
; 134(15)2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-39087472
ABSTRACT
Migraines are a type of headache that occur with other neurological symptoms, but the pathophysiology remains unclear. In this issue of the JCI, Nelson-Maney and authors used constitutive and inducible knockouts of the CGRP receptor components, elegantly demonstrating an essential function of CGRP in modulating meningeal lymphatic vessels (MLVs) in migraine. CGRP was shown to induce rearrangement of membrane-bound gap junction proteins in MLVs, resulting in a reduced CSF flux into cervical lymph nodes. The authors also provided evidence of a primary role for CGRP in modulating neuro-immune function. Finally, by showing that blocking CGRP signaling in MLVs attenuated pain behavior associated with acute migraine in rodents, the authors provided a target for pharmacological blockade of CGRP in relation to primary headache disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Peptídeo Relacionado com Gene de Calcitonina
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Vasos Linfáticos
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Meninges
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Transtornos de Enxaqueca
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Clin Invest
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J. clin. invest
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Journal of clinical investigation
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos