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Establishment and characterization of a rat model of scalp-cranial composite defect for multilayered tissue engineering.
Zhu, Yi; Mei, Ou; Zhang, Hui; You, Wulin; Zhong, Jiamin; Collins, Caralyn P; Shen, Guowei; Luo, Changqi; Wu, Xingye; Li, Jingjing; Shu, Yi; Wen, Ya; Luu, Hue H; Shi, Lewis L; Fan, Jiaming; He, Tong-Chuan; Ameer, Guillermo A; Sun, Cheng; Wen, Liangyuan; Reid, Russell R.
Afiliação
  • Zhu Y; The University of Chicago Medical Center.
  • Mei O; The University of Chicago Medical Center.
  • Zhang H; The University of Chicago Medical Center.
  • You W; The University of Chicago Medical Center.
  • Zhong J; The University of Chicago Medical Center.
  • Collins CP; Northwestern University.
  • Shen G; The University of Chicago Medical Center.
  • Luo C; The University of Chicago Medical Center.
  • Wu X; The University of Chicago Medical Center.
  • Li J; The University of Chicago Medical Center.
  • Shu Y; The University of Chicago Medical Center.
  • Wen Y; Capital Medical University.
  • Luu HH; The University of Chicago Medical Center.
  • Shi LL; The University of Chicago Medical Center.
  • Fan J; The University of Chicago Medical Center.
  • He TC; The University of Chicago Medical Center.
  • Ameer GA; Northwestern University.
  • Sun C; Northwestern University.
  • Wen L; Chinese Academy of Medical Sciences & Peking Union Medical College.
  • Reid RR; The University of Chicago Medical Center.
Res Sq ; 2024 Jul 23.
Article em En | MEDLINE | ID: mdl-39108474
ABSTRACT
Composite cranial defects have individual functional and aesthetic ramifications, as well as societal burden, while posing significant challenges for reconstructive surgeons. Single-stage composite reconstruction of these deformities entail complex surgeries that bear many short- and long-term risks and complications. Current research on composite scalp-cranial defects is sparse and one-dimensional, often focusing solely on bone or skin. Thus, there is an unmet need for a simple, clinically relevant composite defect model in rodents, where there is a challenge in averting healing of the skin component via secondary intention. By utilizing a customizable (3D-printed) wound obturator, the scalp wound can be rendered non-healing for a long period (more than 6 weeks), with the cranial defect patent. The wound obturator shows minimal biotoxicity and will not cause severe endocranium-granulation adhesion. This composite defect model effectively slowed the scalp healing process and preserved the cranial defect, embodying the characteristics of a "chronic composite defect". In parallel, an autologous reconstruction model was established as the positive control. This positive control exhibited reproducible healing of the skin within 3 weeks with variable degrees of osseointegration, consistent with clinical practice. Both models provide a stable platform for subsequent research not only for composite tissue engineering and scaffold design but also for mechanistic studies of composite tissue healing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Res Sq Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Res Sq Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos