Targeting the PINK1/Parkin pathway: A new perspective in the prevention and therapy of diabetic retinopathy.
Exp Eye Res
; 247: 110024, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39117133
ABSTRACT
Diabetic retinopathy (DR) is a microvascular complication of diabetes characterized by neurovascular impairment of the retina. The dysregulation of the mitophagy process occurs before apoptotic cell death and the appearance of vascular damage. In particular, mitochondrial alterations happen during DR development, supporting the hypothesis that mitophagy is negatively correlated to disease progression. This process is mainly regulated by the PTEN-induced putative kinase protein 1 (PINK1)/Parkin pathway whose activation promotes mitophagy. In this review, we will summarize the evidence reported in the literature demonstrating the involvement of the PINK1/Parkin pathway in diabetic retinopathy-induced retinal degeneration.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Ubiquitina-Proteína Ligases
/
Retinopatia Diabética
/
Mitofagia
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Eye Res
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália
País de publicação:
Reino Unido