Your browser doesn't support javascript.
loading
Blood pressure management after endovascular thrombectomy: Insights of recent randomized controlled trials.
Dong, Xiao; Liu, Yuanyuan; Chu, Xuehong; Yu, Erlan; Jia, Xiaole; Ji, Xunming; Wu, Chuanjie.
Afiliação
  • Dong X; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Liu Y; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Chu X; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Yu E; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Jia X; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Ji X; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Wu C; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
CNS Neurosci Ther ; 30(8): e14907, 2024 Aug.
Article em En | MEDLINE | ID: mdl-39118229
ABSTRACT

BACKGROUND:

The ideal blood pressure (BP) target in patients who undergo endovascular thrombectomy (EVT) with successful reperfusion is uncertain. Observational studies show that elevated BP during this period is associated with a higher risk of intracranial hemorrhage (ICH) and worse clinical outcomes. Several randomized controlled trials (RCTs) have explored whether intensive BP lowering improves clinical outcomes in these patients.

AIMS:

This review aims to summarize the recent RCTs that compare intensive and conventional BP management strategies following EVT and discuss the innovative directions to improve.

RESULT:

The recently published RCTs failed to demonstrate the benefit of intensive BP control on the functional outcome and decreasing the risk of ICH. The complex mechanism in cerebral blood flow regulation and the inappropriate BP range chosen in RCTs may be the reasons behind the inconsistent results between observational studies and RCTs. Individualized BP management, reducing BP variability, and multi-stage BP management should be paid more attention in future exploration.

CONCLUSION:

Intensive BP target did not improve clinical outcomes after successful EVT as compared with a conventional BP target. Further research is required to identify the optimal BP management strategy after reperfusion.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Ensaios Clínicos Controlados Aleatórios como Assunto / Trombectomia / Procedimentos Endovasculares Limite: Humans Idioma: En Revista: CNS Neurosci Ther Assunto da revista: NEUROLOGIA / TERAPEUTICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Ensaios Clínicos Controlados Aleatórios como Assunto / Trombectomia / Procedimentos Endovasculares Limite: Humans Idioma: En Revista: CNS Neurosci Ther Assunto da revista: NEUROLOGIA / TERAPEUTICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido