Photoredox/Copper Dual-Catalyzed Phosphorothiolation of Propargylic Derivatives for the Switchable Synthesis of S-Alkyl, S-Vinyl and S-Allenyl Phosphorothioates.

Shi, Shanshan; Chen, Hu; Yang, Shiwei; Dong, Huaze; Zhu, Jinmiao; Zheng, Bin; Wang, Xiaohong; Liang, Zhaoyang; Ren, Hongyu; Gao, Yuzhen

Shi, Shanshan; Chen, Hu; Yang, Shiwei; Dong, Huaze; Zhu, Jinmiao; Zheng, Bin; Wang, Xiaohong; Liang, Zhaoyang; Ren, Hongyu; Gao, Yuzhen.

Afiliação

Shi S; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, 230061, Hefei, Anhui, China.
Chen H; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, 230061, Hefei, Anhui, China.
Yang S; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, 230061, Hefei, Anhui, China.
Dong H; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, 230061, Hefei, Anhui, China.
Zhu J; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, 230061, Hefei, Anhui, China.
Zheng B; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, 230061, Hefei, Anhui, China.
Wang X; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, 230061, Hefei, Anhui, China.
Liang Z; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, 230061, Hefei, Anhui, China.
Ren H; Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, 230061, Hefei, Anhui, China.
Gao Y; State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.

Org Lett ; 26(33): 7049-7054, 2024 Aug 23.

Article em En | MEDLINE | ID: mdl-39119922

ABSTRACT

ABSTRACT

Herein, we report a photoredox/copper dual-catalyzed selective phosphorothiolation of propargylic derivatives from easily accessible [P(O)SH] compounds. This reaction provides a general, mild and versatile procedure to synthesize a variety of synthetically useful S-alkyl, S-vinyl and S-allenyl phosphorothioates selectively from the same set of simple starting materials.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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