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Breast, Colorectal, and Prostate Cancer Incidence among Filipino Americans by Generational Status in the Multiethnic Cohort Study.
Abe, Janine V; Legaspi, Justin; Guillermo, Cherie; Bogumil, David; Setiawan, Veronica Wendy; Le Marchand, Loïc; Hernandez, Brenda Y; Wilkens, Lynne R; Maskarinec, Gertraud.
Afiliação
  • Abe JV; Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • Legaspi J; Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • Guillermo C; Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • Bogumil D; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
  • Setiawan VW; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
  • Le Marchand L; Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • Hernandez BY; Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • Wilkens LR; Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • Maskarinec G; Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Cancer Epidemiol Biomarkers Prev ; 33(10): 1311-1317, 2024 Oct 02.
Article em En | MEDLINE | ID: mdl-39132985
ABSTRACT

BACKGROUND:

Filipino Americans constitute 12% and 4% of the respective populations of Hawaii and California, with a large proportion of immigrants experiencing increasing cancer rates. This study investigated the incidence of colorectal, breast, and prostate cancers by generational status in the Multiethnic Cohort.

METHODS:

We analyzed 10,495 Filipino Multiethnic Cohort first-, second-, and third-generation participants, in which 26.8% were of mixed race and ethnicity. Linkage to statewide cancer registries identified 375 breast, 249 colorectal, and 436 prostate cancer incident cases. Cox models were used to calculate HRs and 95% confidence intervals (CI) for the association between generational status and cancer incidence. Models were adjusted for age at cohort entry and cancer-specific covariates that were chosen based on stepwise regression.

RESULTS:

Compared with the first generation, colorectal cancer showed a significantly higher incidence in the second and third generations with respective HRs of 1.43 (95% CI, 1.04, 1.98) and 1.76 (95% CI, 1.29, 2.38). This association was attenuated after adjustment for relevant covariates. Breast cancer incidence was elevated in the third versus first generation (HR = 1.29; 95% CI, 1.01, 1.63) even in the fully adjusted model, whereas little difference was observed for prostate cancer.

CONCLUSIONS:

In this prospective study, we found differences in incidence by generational status, specifically colorectal cancer among men and female breast cancer. IMPACT Understanding behavioral changes due to acculturation is warranted to mitigate cancer risks in migrant populations.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Neoplasias da Mama / Neoplasias Colorretais / Asiático Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte / Asia Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Assunto da revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Neoplasias da Mama / Neoplasias Colorretais / Asiático Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do norte / Asia Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Assunto da revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos