Impact on neonatal morbidity of moderate to severe early foetal growth restriction defined by doppler criteria: multicentre study.
An Pediatr (Engl Ed)
; 101(2): 104-114, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-39138032
ABSTRACT
INTRODUCTION:
In recent years, there has been a change in the conceptualization of foetal growth restriction (FGR), which has gone from being defined solely based on weight criteria to being defined and staged based on Doppler criteria. The aim of our study was to evaluate neonatal risk in a cohort of neonates with moderate to severe early-onset FGR defined by Doppler criteria. POPULATION ANDMETHODS:
We conducted a multicentre prospective cohort study in a cohort of neonates with early-onset foetal growth restriction and abnormal Doppler findings and a control cohort without Doppler abnormalities matched for sex and gestational age.RESULTS:
A total of 105 patients (50 cases, 55 controls) were included. We found a higher frequency of respiratory morbidity in the FGR group, with an increased need of surfactant (30% vs. 27.3%; OR, 5.3 [95% CI, 1.1-26.7]), an increased need for supplemental oxygen (66% vs. 49.1%; OR, 5.6 [95% CI, 1.5-20.5]), and a decreased survival without bronchopulmonary dysplasia (70 vs. 87.3%; OR, 0.16 [95% CI, 0.03-0.99]). Patients with FGR required a longer length of stay and more days of parenteral nutrition and had a higher incidence of haematological abnormalities such as neutropenia and thrombopenia. The lactate level at birth was higher in the severe FGR subgroup (6.12 vs. 2.4â¯mg/dL; P = .02).CONCLUSION:
The diagnosis of early-onset moderate to severe FGR defined by Doppler criteria carries a greater risk of respiratory, nutritional and haematological morbidity, independently of weight and gestational age. These patients, therefore, should be considered at increased risk compared to constitutionally small for gestational age preterm infants or preterm infants without FGR.Palavras-chave
Bajo peso para la edad gestacional (BPEG); Crecimiento intrauterino restringido (CIR); Doppler prenatal; Foetal growth restriction (FGR); Intrauterine growth restriction; Neonate; Neonato; Prenatal Doppler; Preterm; Pretérmino; Small for gestational age (SGA); umbIlical artery pulsatility index; Índice pulsatilidad en arteria umbilical
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
/
Retardo do Crescimento Fetal
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
An Pediatr (Engl Ed)
/
An. pediatr. (Internet, Engl. ed.)
/
Anales de pediatria (Internet. English ed.)
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Espanha