Predictive value of Vitamin D levels in pregnant women on gestational length and neonatal weight in China: a population-based retrospective study.
Reprod Biol Endocrinol
; 22(1): 102, 2024 Aug 13.
Article
em En
| MEDLINE
| ID: mdl-39138489
ABSTRACT
BACKGROUND:
Vitamin D deficiency, a common occurrence among pregnant women, is an emerging public health concern worldwide. According to research, prenatal vitamin D deficiency is associated with various complications. This study assessed the vitamin D status of pregnant women in Yanbian, Jilin Province, as well as the correlation and predictive value of their vitamin D levels in relation to gestational length (weeks) and fetal weight, aiming to provide a basis for clinical diagnosis and treatment.METHODS:
We conducted a population-based retrospective study involving 510 pregnant women from August 2019 to October 2022. Blood samples were collected at 16-20 weeks of gestation for the detection of serum vitamin D levels. Statistical analyses were performed using SPSS 28.0 and R 4.1.0 software. Multifactorial logistic regression analysis was employed to establish whether each variable was a risk factor for deliveries at ≤ 38 gestational weeks and low fetal weight. These results were used to construct a risk prediction model, and the model's predictive efficacy was evaluated. Results or differences with p < 0.05 were considered statistically significant.RESULTS:
Multifactorial logistic regression analysis revealed that vitamin D ≤ 14.7 ng/mL(OR 1.611; 95% CI 1.120-2.318; P = 0.010), Bone Mineral Density (BMD) T-value ≤-1(OR 1.540; 95%CI 1.067-2.223; P = 0.021), and gestational hypertension(OR 7.173; 95% CI 1.482-34.724; P = 0.014) were the independent risk factors for deliveries at ≤ 38 gestational weeks. Additionally, vitamin D ≤ 14.7 ng/mL(OR 1.610; 95%CI 1.123-2.307; P = 0.009), BMD T-value ≤ -1(OR 1.560; 95%CI 1.085-2.243; P = 0.016), and gestational hypertension(OR 4.262; 95% CI 1.058-17.167; P = 0.041) were the independent risk factors for low fetal weight (< 3400 g).CONCLUSION:
This study revealed that low vitamin D levels are an independent risk factor for a short gestational length and low fetal weight. Prenatal low BMD T-value and comorbid hypertensive disorders were also found to increase the risk of a short gestational length and low fetal weight.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Peso ao Nascer
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
Reprod Biol Endocrinol
Assunto da revista:
ENDOCRINOLOGIA
/
MEDICINA REPRODUTIVA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Reino Unido