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Bacteria modulate microalgal aging physiology through the induction of extracellular vesicle production to remove harmful metabolites.
Deng, Yun; Yu, Ruyi; Grabe, Veit; Sommermann, Thomas; Werner, Markus; Vallet, Marine; Zerfaß, Christian; Werz, Oliver; Pohnert, Georg.
Afiliação
  • Deng Y; Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Jena, Germany.
  • Yu R; Balance of the Microverse Cluster of Excellence, Friedrich Schiller University Jena, Jena, Germany.
  • Grabe V; Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Jena, Germany.
  • Sommermann T; Imaging Platform, Max Planck Institute for Chemical Ecology, Jena, Germany.
  • Werner M; Department of Infection Immunology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
  • Vallet M; Department for Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena, Germany.
  • Zerfaß C; Max Planck Fellow Group Plankton Community Interaction, Max Planck Institute for Chemical Ecology, Jena, Germany.
  • Werz O; Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Jena, Germany.
  • Pohnert G; Department for Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena, Germany.
Nat Microbiol ; 9(9): 2356-2368, 2024 Sep.
Article em En | MEDLINE | ID: mdl-39143356
ABSTRACT
The bloom and bust patterns of microalgae in aquatic systems contribute massively to global biogeochemical cycles. The decline of algal blooms is mainly caused by nutrient limitation resulting in cell death, the arrest of cell division and the aging of surviving cells. Nutrient intake can re-initiate proliferation, but the processes involved are poorly understood. Here we characterize how the bloom-forming diatom Coscinodiscus radiatus recovers from starvation after nutrient influx. Rejuvenation is mediated by extracellular vesicles that shuttle reactive oxygen species, oxylipins and other harmful metabolites out of the old cells, thereby re-enabling their proliferation. By administering nutrient pulses to aged cells and metabolomic monitoring of the response, we show that regulated pathways are centred around the methionine cycle in C. radiatus. Co-incubation experiments show that bacteria mediate aging processes and trigger vesicle production using chemical signalling. This work opens new perspectives on cellular aging and rejuvenation in complex microbial communities.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espécies Reativas de Oxigênio / Diatomáceas / Microalgas / Vesículas Extracelulares Idioma: En Revista: Nat Microbiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espécies Reativas de Oxigênio / Diatomáceas / Microalgas / Vesículas Extracelulares Idioma: En Revista: Nat Microbiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido