Causal relationship between telomere length and osteonecrosis: Bidirectional two-sample Mendelian randomization analysis.
Medicine (Baltimore)
; 103(33): e39324, 2024 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-39151532
ABSTRACT
Recent mounting evidence suggests that shortening of telomere length (TL) is associated with impaired bone health; yet, a genetic causal relationship between TL and osteonecrosis remains uncertain. This study aimed to investigate the potential causal relationship between TL and osteonecrosis using bidirectional two-sample Mendelian randomization (MR). Genome-wide association study summary statistics for TL were sourced from the IEU Open genome-wide association study project, while osteonecrosis data were obtained from the FinnGen Biobank database. A range of MR methodologies-including inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode-were utilized for analysis, along with the MR-Egger intercept method for horizontal pleiotropy assessment, and Cochran Q and leave-one-out methods for heterogeneity testing. The forward MR analysis indicated a significant causal relationship between TL and osteonecrosis, suggesting that genetically predicted shorter TL is associated with an elevated risk of developing osteonecrosis (ORâ
=â
0.611, 95% confidence interval 0.394-0.948, Pâ
=â
.028). The reverse MR analysis revealed no significant influence of osteonecrosis on TL (ORâ
=â
0.999, 95% confidence interval 0.994-1.005, Pâ
=â
.802). Analyses for heterogeneity and horizontal pleiotropy yielded robust results. Our study demonstrates that individuals with shorter TL have an increased risk of developing osteonecrosis, whereas osteonecrosis has no effect on TL.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteonecrose
/
Estudo de Associação Genômica Ampla
/
Análise da Randomização Mendeliana
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Estados Unidos