Your browser doesn't support javascript.
loading
Association between cognitive functioning, suicidal ideation and suicide attempts in major depressive disorder, bipolar disorder, schizophrenia and related disorders: A systematic review and meta-analysis.
Le, Gia Han; Wong, Sabrina; Haikazian, Sipan; Johnson, Danica E; Badulescu, Sebastian; Kwan, Angela T H; Gill, Hartej; Di Vincenzo, Joshua D; Rosenblat, Joshua D; Mansur, Rodrigo; Teopiz, Kayla M; Rhee, Taeho Greg; Ho, Roger; Liao, Sonya; Cao, Bing; Schweinfurth-Keck, Nina; Vinberg, Maj; Grande, Iria; Phan, Lee; d'Andrea, Giacomo; McIntyre, Roger S.
Afiliação
  • Le GH; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Canada. Electronic address: hanny.le@mail.utoronto.ca.
  • Wong S; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada. Electronic address: sabrinal.wong@mail.utoronto.ca.
  • Haikazian S; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada. Electronic address: sipan.haikazian@uhn.ca.
  • Johnson DE; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada. Electronic address: danica.johnson@uhn.ca.
  • Badulescu S; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Canada. Electronic address: sebastian.badulescu@mail.utoronto.ca.
  • Kwan ATH; Brain and Cognition Discovery Foundation, Toronto, Canada; Faculty of Medicine, University of Ottawa, Ottawa, Canada. Electronic address: angela.kwan@mail.utoronto.ca.
  • Gill H; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada. Electronic address: hartej.gill@utoronto.ca.
  • Di Vincenzo JD; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada. Electronic address: joshua.divincenzo@uhn.ca.
  • Rosenblat JD; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Cana
  • Mansur R; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada. Electronic address: rodrigo.mansur@uhn.ca.
  • Teopiz KM; Brain and Cognition Discovery Foundation, Toronto, Canada. Electronic address: kayla.teopiz@mail.utoronto.ca.
  • Rhee TG; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Public Health Sciences, University of Connecticut School of Medicine, Farmington, CT, USA. Electronic address: taeho.rhee@yale.edu.
  • Ho R; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, Singapore. Electronic address: pcmrhcm@nus.edu.sg.
  • Liao S; Brain and Cognition Discovery Foundation, Toronto, Canada. Electronic address: sonya.liao@mail.utoronto.ca.
  • Cao B; Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University, Chongqing 400715, PR China. Electronic address: bingcao@swu.edu.cn.
  • Schweinfurth-Keck N; Center of Affective, Stress-related and Sleep Disorders (ZASS), University Medical Centers Basel (UPK), Basel, Switzerland; University of Basel, Department of Psychiatry, Basel, Switzerland. Electronic address: nina.schweinfurth-keck@upk.ch.
  • Vinberg M; The Early Multimodular Prevention and Intervention Research Institution (EMPIRI), Mental Health Centre, Northern Zealand, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.
  • Grande I; Departament de Medicina, Facultat de Medicina i Ciències de la Salut, (UB), c. Casanova, 143, 08036 Barcelona, Spain; Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona, c. Villarroel, 170, 08036 Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), c
  • Phan L; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada.
  • d'Andrea G; Department of Neurosciences, Imaging and Clinical Sciences, Università degli Studi G. D'Annunzio, Chieti, Italy.
  • McIntyre RS; Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada. Electro
J Affect Disord ; 365: 381-399, 2024 Nov 15.
Article em En | MEDLINE | ID: mdl-39168166
ABSTRACT

INTRODUCTION:

Treatable mental disorders, such as psychotic, major depressive disorder (MDD), and bipolar disorder (BD), contribute to a substantial portion of suicide risk, often accompanied by neurocognitive deficits. We report the association between cognitive function and suicidal ideation/suicide attempts (SI/SA) in individuals with schizoaffective disorder, BD, and MDD.

METHODS:

A systematic search was conducted on PubMed, Ovid and Scopus databases for primary studies published from inception to April 2024. Eligible articles that reported on the effect size of association between cognition and SI/SA were pooled using a random effects model.

RESULTS:

A total of 41 studies were included for analysis. There was a negative association between executive functioning and SI/SA in schizoaffective disorder (SA Corr = -0·78, 95 % CI [-1·00, 0·98]; SI Corr = -0·06, 95 % CI [-0·85, 0·82]) and MDD (SA Corr = -0·227, 95 % CI [-0·419, -0·017]; SI Corr = -0·14, 95 % CI [-0·33, 0·06]). Results were mixed for BD, with a significant positive association between SA and global executive functioning (Corr = 0·08, 95 % CI [0·01, 0·15]) and negative association with emotion inhibition. Mixed results were observed for processing speed, attention, and learning and memory, transdiagnostically.

LIMITATIONS:

There is heterogeneity across sample compositions and cognitive measures. We did not have detailed information on individuals with respect to demographics and comorbidities.

CONCLUSIONS:

We observed a transdiagnostic association between measures of cognitive functions and aspects of suicidality. The interplay of cognitive disturbances, particularly in reward-based functioning, may underlie suicidality in individuals with mental disorders. Disturbances in impulse control, planning, and working memory may contribute to self-injurious behavior and suicide.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Tentativa de Suicídio / Transtorno Bipolar / Transtorno Depressivo Maior / Ideação Suicida Limite: Humans Idioma: En Revista: J Affect Disord Ano de publicação: 2024 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Tentativa de Suicídio / Transtorno Bipolar / Transtorno Depressivo Maior / Ideação Suicida Limite: Humans Idioma: En Revista: J Affect Disord Ano de publicação: 2024 Tipo de documento: Article País de publicação: Holanda