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Epidemiological Study in Antiviral Innate Immunity.
Zhao, Xiaoyu; Liu, Yuting; Cheng, Ruogu; Zheng, Chunfu; Shang, Pei.
Afiliação
  • Zhao X; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
  • Liu Y; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
  • Cheng R; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
  • Zheng C; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.
  • Shang P; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. Shang.Pei@Mayo.edu.
Methods Mol Biol ; 2854: 189-197, 2025.
Article em En | MEDLINE | ID: mdl-39192130
ABSTRACT
This chapter summarizes the epidemiological study design of natural immune epidemiology studies based on recent COVID-19-related research. The epidemiological studies on antiviral innate immunity have mainly included randomized controlled trials (RCTs) and observational studies. Importantly, this chapter will discuss how to use these methodologies to answer an epidemiological question of natural immunity in the viral infection process based on previous studies. An observational case- or cohort-based study of antiviral innate immunity may support this theoretical hypothesis but is not appropriate for clinical practice or treatment. RCTs are the gold standard for epidemiological studies and occupy a greater role in the hierarchy of evidence.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 / Imunidade Inata Limite: Humans Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2025 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 / Imunidade Inata Limite: Humans Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2025 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos