Small Nucleolar RNAs in Solid Tumors: A Brief Review of the Literature on These Potential Biomarkers.
Asian Pac J Cancer Prev
; 25(8): 2585-2591, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-39205555
ABSTRACT
OBJECTIVE:
The objective of this study was to conduct an integrative review, addressing the key findings, biological functions, and clinical significance of these biomolecules in solid tumors.METHODS:
This document analyzes the main data on the involvement of snoRNAs in solid tumors. For this, Pubmed and Science direct were used, with keywords. Additionally, a search for the host gene was conducted using the snoDB tool, and its chromosomal location was identified using the Hugo Gene Nomenclature Committee (HGNC).RESULTS:
According to research conducted in the literature, the majority of snoRNAs were found to be overexpressed and described as regulators of processes such as invasion, cellular proliferation, apoptosis, and migration. They are associated with clinical prognostic factors such as metastasis and worse survival.CONCLUSION:
Therefore, it is essential to expand the investigation of snoRNAs in oncology across different types of tumors. The utilization of these biomolecules may pave the way for innovative clinical applications, such as their use in the early detection of neoplasms in non-invasive samples and as therapeutic targets. Broadening research on snoRNAs across various tumor types is crucial.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
RNA Nucleolar Pequeno
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Asian Pac J Cancer Prev
/
Asian pac. j. cancer prev
/
Asian pacific journal of cancer prevention
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Tailândia