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Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases.
Liang, Wendanqi; Luo, Yi; Xu, Ajing; Chu, Jianjian; Ji, Wenbo; Wang, Li; Gu, Yuankai; Lu, Xinyu; Hou, Along; Liu, Yan; Gao, Jie; Yin, You.
Afiliação
  • Liang W; Department of Neurology, Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University, Shanghai, China.
  • Luo Y; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
  • Xu A; New Drug Discovery and Development, Biotheus Inc., Zhuhai, China.
  • Chu J; Clinical Pharmacy Innovation Institute, Shanghai Jiao Tong University of Medicine, Shanghai, China.
  • Ji W; Clinical Pharmacy Innovation Institute, Shanghai Jiao Tong University of Medicine, Shanghai, China.
  • Wang L; Department of Clinical Pharmacy, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Gu Y; Department of Neurology, Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University, Shanghai, China.
  • Lu X; Department of Neurology, Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University, Shanghai, China.
  • Hou A; Department of Neurology, Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University, Shanghai, China.
  • Liu Y; Department of Neurology, Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University, Shanghai, China.
  • Gao J; Department of Neurology, Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University, Shanghai, China.
  • Yin Y; Department of Neurology, Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University, Shanghai, China.
Biomater Sci ; 12(19): 4927-4945, 2024 Sep 25.
Article em En | MEDLINE | ID: mdl-39206575
ABSTRACT
Neurodegenerative diseases are devastating diseases that severely affect the health of people all over the world. RNA therapies have become one of the most promising critical drug treatments for neurodegenerative diseases due to their excellent gene and protein editing effects. However, the successful transport of RNA via the systemic route to the central nervous system remains one of the major obstacles in treating neurodegenerative diseases. This review will focus on therapeutic RNA that can successfully overcome the blood-brain barrier (BBB), with particular attention to small interfering RNAs (siRNAs), focusing on different types of neurodegenerative disease treatment strategies and accelerating their translation into clinical practice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Doenças Neurodegenerativas / RNA Interferente Pequeno Limite: Animals / Humans Idioma: En Revista: Biomater Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Doenças Neurodegenerativas / RNA Interferente Pequeno Limite: Animals / Humans Idioma: En Revista: Biomater Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido