DNA binding studies and in-vitro anticancer studies of novel lanthanide complexes.

Zhang, Yuehong; Li, Xinshu; Li, Kaisu; Wang, Ling; Luo, Xin; Zhang, Ying; Sun, Na; Zhu, Mingchang

Zhang, Yuehong; Li, Xinshu; Li, Kaisu; Wang, Ling; Luo, Xin; Zhang, Ying; Sun, Na; Zhu, Mingchang.

Afiliação

Zhang Y; The Key Laboratory of the Inorganic Molecule-based Chemistry of Liaoning Province and Laboratory of Coordination, College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China.
Li X; The Key Laboratory of the Inorganic Molecule-based Chemistry of Liaoning Province and Laboratory of Coordination, College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China.
Li K; The Key Laboratory of the Inorganic Molecule-based Chemistry of Liaoning Province and Laboratory of Coordination, College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China.
Wang L; The Key Laboratory of the Inorganic Molecule-based Chemistry of Liaoning Province and Laboratory of Coordination, College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China.
Luo X; The Key Laboratory of the Inorganic Molecule-based Chemistry of Liaoning Province and Laboratory of Coordination, College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China.
Zhang Y; The Key Laboratory of the Inorganic Molecule-based Chemistry of Liaoning Province and Laboratory of Coordination, College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China.
Sun N; The Key Laboratory of the Inorganic Molecule-based Chemistry of Liaoning Province and Laboratory of Coordination, College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China; School of Materials Science and Engineering, National Institute for Advanced Materials, TKL of Met
Zhu M; The Key Laboratory of the Inorganic Molecule-based Chemistry of Liaoning Province and Laboratory of Coordination, College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China; College of Environmental and Safety Engineering, Shenyang University of Chemical Technology, Sheny

Int J Biol Macromol ; 279(Pt 1): 135048, 2024 Aug 30.

Article em En | MEDLINE | ID: mdl-39208896

ABSTRACT

ABSTRACT

Pancreatic cancer, is an aggressive type of cancer and the most common malignancy with a poor prognosis regarding metastatic disease (survival < 10 %). The development of Novel chemotherapeutic drugs holds significant prospects for practical applications. Here, this work focuses on the interaction between two lanthanide complexes, Yb-BZA and Er-BZA, with DNA, as well as their anticancer activity against pancreatic cancer. The relationship between complexes and DNA is revealed by fluorescence, absorption spectral titration, cyclic voltammetric (CV) experiments, indicating that the Yb-BZA and Er-BZA interact with FS-DNA by bind groove. Moreover, molecular docking technology was utilized to confirm the binding of Yb-BZA and Er-BZA with 1BNA and 4AV1. The cytotoxic effects of Yb-BZA and Er-BZA on cancer cells BxPC-3 were evaluated, Yb-BZA (IC50 = 6.459 µg/mL) is more effective than oxaliplatin (IC50 = 16.46 µg/mL) evaluated using cytotoxicity assay. Yb-BZA and Er-BZA has the potential to become a chemotherapy drug for pancreatic cancer cells.

Palavras-chave

Cell in vitro research; DNA binding studies; Pancreatic cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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