Blood cell counts and nonalcoholic fatty liver disease: Evidence from Mendelian randomization analysis.
World J Hepatol
; 16(8): 1145-1155, 2024 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-39221100
ABSTRACT
BACKGROUND:
Previous research has highlighted correlations between blood cell counts and chronic liver disease. Nonetheless, the causal relationships remain unknown.AIM:
To evaluate the causal effect of blood cell traits on liver enzymes and nonalcoholic fatty liver disease (NAFLD) risk.METHODS:
Independent genetic variants strongly associated with blood cell traits were extracted from a genome-wide association study (GWAS) conducted by the Blood Cell Consortium. Summary-level data for liver enzymes were obtained from the United Kingdom Biobank. NAFLD data were obtained from a GWAS meta-analysis (8434 cases and 770180 controls, discovery dataset) and the Fingen GWAS (2275 cases and 372727 controls, replication dataset). This analysis was conducted using the inverse-variance weighted method, followed by various sensitivity analyses.RESULTS:
One SD increase in the genetically predicted haemoglobin concentration (HGB) was associated with a ß of 0.0078 (95%CI 0.0059-0.0096), 0.0108 (95%CI 0.0080-0.0136), 0.0361 (95%CI 0.0156-0.0567), and 0.0083 (95%CI 00046-0.0121) for alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase, and gamma-glutamyl transferase, respectively. Genetically predicted haematocrit was associated with ALP (ß = 0.0078, 95%CI 0.0052-0.0104) and ALT (ß = 0.0057, 95%CI 0.0039-0.0075). Genetically determined HGB and the reticulocyte fraction of red blood cells increased the risk of NAFLD [odds ratio (OR) = 1.199, 95%CI 1.087-1.322] and (OR = 1.157, 95%CI 1.071-1.250). The results of the sensitivity analyses remained significant.CONCLUSION:
Novel causal blood cell traits related to liver enzymes and NAFLD development were revealed through Mendelian randomization analysis, which may facilitate the diagnosis and prevention of NAFLD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
World J Hepatol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Estados Unidos