Efficacy of biologics for eosinophilic otitis media.
Acta Otolaryngol
; : 1-7, 2024 Sep 03.
Article
em En
| MEDLINE
| ID: mdl-39225680
ABSTRACT
BACKGROUND:
Eosinophilic otitis media (EOM) is an intractable condition primarily treated with steroids. Recently, biologics targeting IgE or IL-5 have been introduced.OBJECTIVES:
This study aimed to evaluate the efficacy of biologics for EOM. MATERIALS ANDMETHODS:
We retrospectively collected data on EOM patients treated from January 2008 to December 2020 from electronic medical records. Patients were classified into the steroid group, treated with systemic or local steroids, and the biologics group, treated with biologics with or without steroids.RESULTS:
The otorrhea remission rate was 63.33% in the steroid group, comparable to 58.82% in the biologics group (p = 0.760). Before treatment, the steroid group showed better bone-conduction (BC) thresholds at 0.5 kHz and 1 kHz than the biologics group. Post-treatment, the steroid group improved in air-conduction (AC) threshold and air-bone gap (ABG) at 1 kHz and 2 kHz. The biologics group exhibited stable audiological results. No significant differences were observed post-treatment between the groups, except for the BC threshold at 0.5 kHz, which remained as pre-treatment. CONCLUSIONS ANDSIGNIFICANCE:
Biologics demonstrated similar efficacy in otorrhea remission as steroids and might help maintain hearing levels. Biologics can be considered for controlling EOM with active otorrhea and reducing systemic steroid use.
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Acta Otolaryngol
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Reino Unido