Genomic Landscape of Pancreatic Neuroendocrine Tumors and Implications for Clinical Practice.
JCO Precis Oncol
; 8: e2400221, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39231376
ABSTRACT
Pancreatic neuroendocrine tumors (pNETs) are the second most prevalent neoplasms of the pancreas with variable prognosis and clinical course. Our knowledge of the genetic alterations in patients with pNETs has expanded in the past decade with the availability of whole-genome sequencing and germline testing. This review will focus on potential clinical applications of the genetic testing in patients with pNETs. For somatic testing, we discuss the commonly prevalent somatic mutations and their impact on prognosis and treatment of patients with pNET. We also highlight the relevant genomic biomarkers that predict response to specific treatments. Previously, germline testing was only recommended for high-risk patients with syndromic features (MEN1, VHL, TSC, and NF1), we review the evolving paradigm of germline testing in pNETs as recent studies have now shown that sporadic-appearing pNETs can also harbor germline variants.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Tumores Neuroendócrinos
Limite:
Humans
Idioma:
En
Revista:
JCO Precis Oncol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Moldávia
País de publicação:
Estados Unidos