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Individualized tacrolimus therapy: Insights from CYP3A5 polymorphisms and intestinal metabolism.
Mishima, Mizuki; Yabe, Tomohisa; Kondo, Takaya; Fujimoto, Keiji; Takata, Ryoji; Yokoyama, Hitoshi; Niida, Yo; Tanaka, Tatsuro; Miyazawa, Katsuhito; Furuichi, Kengo.
Afiliação
  • Mishima M; Department of Nephrology Kanazawa Medical University Kahoku Japan.
  • Yabe T; Department of Nephrology Kanazawa Medical University Kahoku Japan.
  • Kondo T; Department of Nephrology Kanazawa Medical University Kahoku Japan.
  • Fujimoto K; Department of Nephrology Kanazawa Medical University Kahoku Japan.
  • Takata R; Department of Pharmacy Kanazawa Medical University Hospital Kahoku Japan.
  • Yokoyama H; Department of Nephrology Kanazawa Medical University Kahoku Japan.
  • Niida Y; Division of Genomic Medicine, Department of Advanced Medicine, Medical Research Institute Kanazawa Medical University Kahoku Japan.
  • Tanaka T; Center for Clinical Genomics Kanazawa Medical University Hospital Kahoku Japan.
  • Miyazawa K; Department of Urology Kanazawa Medical University Kahoku Japan.
  • Furuichi K; Department of Urology Kanazawa Medical University Kahoku Japan.
Clin Case Rep ; 12(9): e9416, 2024 Sep.
Article em En | MEDLINE | ID: mdl-39247561
ABSTRACT
CYP3A4 and CYP3A5 are the most abundant and important enzymes of the CYP3A subfamily, distributed in the liver, intestinal mucosa and kidney, and involved in tacrolimus metabolism. Here, we report a case of tacrolimus dosage refractoriness due to a genetic polymorphism of CYP3A5.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Case Rep Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Case Rep Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido