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The relative associations of aortic and carotid artery stiffness with CeVD and cognition.
Robert, Caroline; Ling, Lieng-Hsi; Tan, Eugene Sj; Venketasubramanian, Narayanaswamy; Lim, Shir Lynn; Gong, Lingli; Berboso, Josephine Lunaria; Richards, Arthur Mark; Chen, Christopher; Hilal, Saima.
Afiliação
  • Robert C; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Ling LH; Memory Aging and Cognition Centre, National University Health System, Singapore.
  • Tan ES; Department of Cardiology, National University Heart Centre, Singapore.
  • Venketasubramanian N; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Lim SL; Department of Cardiology, National University Heart Centre, Singapore.
  • Gong L; Raffles Neuroscience Centre, Raffles Hospital, Singapore.
  • Berboso JL; Department of Cardiology, National University Heart Centre, Singapore.
  • Richards AM; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Chen C; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Hilal S; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
J Cereb Blood Flow Metab ; : 271678X241281137, 2024 Sep 10.
Article em En | MEDLINE | ID: mdl-39253823
ABSTRACT
We examined the relative associations of aortic and carotid artery stiffness with cerebrovascular disease (CeVD), cognition, and dementia subtypes in a memory clinic cohort of 272 participants (mean age = 75.4, SD = 6.8). We hypothesized that carotid artery stiffness would have greater effects on outcomes, given its proximate relationship to the brain. Aortic and carotid artery stiffness were assessed with applanation tonometry and carotid ultrasonography, respectively. CeVD markers included white matter hyperintensities (WMH), lacunes, cerebral microbleeds, cortical infarcts, and intracranial stenosis. Cognition was assessed by the Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and a neuropsychological battery. Multivariable linear regression was conducted to determine associations of arterial stiffness with WMH and cognition, while logistic regression analysed associations with CeVD markers and dementia subtypes. Carotid artery stiffness z-score was associated with WMH, cortical infarcts, vascular cognitive impairment, and MMSE, independent of age, sex, education, vascular risk factors, and aortic stiffness z-score. Although aortic stiffness z-score was independently associated with cortical infarcts, this became non-significant after further adjusting for carotid artery stiffness z-score. We found that carotid artery stiffness had greater effects on CeVD, cognitive function and impairment in memory clinic patients compared to aortic stiffness.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Singapura País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Singapura País de publicação: Estados Unidos