CNS prophylaxis in large B-cell lymphomas: A balance with three pans.

ABSTRACT

Given the significant limitations of available literature, central nervous system (CNS) prophylaxis in large B-cell lymphomas remains debatable. Wilson and colleagues provide cautious recommendations, on a case-by-case basis, useful to guide discussion with individual patient. In daily practice, CNS relapse risk, prophylaxis safety and prognosis of CNS recurrence must be considered. Commentary on Wilson et al. Central nervous system prophylaxis in large B-cell lymphoma A British Society for Haematology Good Practice Paper. Br J Haematol 2024 (Online ahead of print). doi 10.1111/bjh.19686.