Instrumented timed up and go test and machine learning-based levodopa response evaluation: a pilot study.
J Neuroeng Rehabil
; 21(1): 163, 2024 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-39294708
ABSTRACT
BACKGROUND:
The acute levodopa challenge test (ALCT) is a universal method for evaluating levodopa response (LR). Assessment of Movement Disorder Society's Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS III) is a key step in ALCT, which is some extent subjective and inconvenience.METHODS:
This study developed a machine learning method based on instrumented Timed Up and Go (iTUG) test to evaluate the patients' response to levodopa and compared it with classic ALCT. Forty-two patients with parkinsonism were recruited and administered with levodopa. MDS-UPDRS III and the iTUG were conducted in both OFF-and ON-medication state. Kinematic parameters, signal time and frequency domain features were extracted from sensor data. Two XGBoost models, levodopa response regression (LRR) model and motor symptom evaluation (MSE) model, were trained to predict the levodopa response (LR) of the patients using leave-one-subject-out cross-validation.RESULTS:
The LR predicted by the LRR model agreed with that calculated by the classic ALCT (ICC = 0.95). When the LRR model was used to detect patients with a positive LR, the positive predictive value was 0.94.CONCLUSIONS:
Machine learning based on wearable sensor data and the iTUG test may be effective and comprehensive for evaluating LR and predicting the benefit of dopaminergic therapy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Levodopa
/
Aprendizado de Máquina
/
Antiparkinsonianos
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Neuroeng Rehabil
Assunto da revista:
ENGENHARIA BIOMEDICA
/
NEUROLOGIA
/
REABILITACAO
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Reino Unido