Akkermansia in the gastrointestinal tract as a modifier of human health.
Gut Microbes
; 16(1): 2406379, 2024.
Article
em En
| MEDLINE
| ID: mdl-39305271
ABSTRACT
Akkermansia sp are common members of the human gut microbiota. Multiple reports have emerged linking the abundance of A. muciniphila to health benefits and disease risk in humans and animals. This review highlights findings linking Akkermansia species in the gastrointestinal (GI) tract to health outcomes across a spectrum of disorders, encompassing those that affect the digestive, respiratory, urinary, and central nervous systems. The mechanism through which Akkermansia exerts a beneficial versus a detrimental effect on health is likely dependent on the genetic makeup of the host metabolic capacity and immunomodulatory properties of the strain, the competition or cooperation with other members of the host microbiota, as well as synergy with co-administered therapies.
Palavras-chave
AD; ALS; ASD; Akkermansia muciniphila; CKD; Clostridium difficile; GVHD; IBD; LCMV; MS; NAFLD; PD; Salmonella typhimurium; asthma; biwaensis; cancer; diabetes; durhamii; epilepsy; helminth; ignis; immunotherapy; infections; influenza; liver; massiliensis; microbiota; nephropathy; neurological disease; obesity; sepsis; tuberculosis
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trato Gastrointestinal
/
Microbioma Gastrointestinal
/
Akkermansia
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Gut Microbes
/
Gut microbes
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos