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Previous Use of Combined Oral Contraception in High Complexity Assisted Reproduction Treatments in Protocol with Oral Progestin - Previous use of COC and ART.
Vidal, Daniel Henrique Braga; Gentil, Fabiana Lanoli; Montagna, Erik; Barbosa, Caio Parente; Oliveira, Renato de.
Afiliação
  • Vidal DHB; Centro Universitário FMABC, Departamento de Saúde Coletiva - Setor de Reprodução Humana - Instituto Ideia Fértil - Santo André, São Paulo, Brazil.
  • Gentil FL; Centro Universitário FMABC, Departamento de Saúde Coletiva - Setor de Reprodução Humana - Instituto Ideia Fértil - Santo André, São Paulo, Brazil.
  • Montagna E; Centro Universitário FMABC, Pós-graduação - Santo André, São Paulo, Brazil.
  • Barbosa CP; Centro Universitário FMABC, Departamento de Saúde Coletiva - Setor de Reprodução Humana - Instituto Ideia Fértil - Santo André, São Paulo, Brazil.
  • Oliveira R; Centro Universitário FMABC, Departamento de Saúde Coletiva - Setor de Reprodução Humana - Instituto Ideia Fértil - Santo André, São Paulo, Brazil.
JBRA Assist Reprod ; 2024 Sep 23.
Article em En | MEDLINE | ID: mdl-39311653
ABSTRACT

OBJECTIVE:

To evaluate the impact of prior use of combined oral contraceptives in assisted reproduction techniques with ovulation blockade by oral progestin.

METHODS:

Retrospective cohort study with a single-center convenience sample of patients treated between 2018 and 2021. Two groups were compared with and without a history of combined oral contraceptives (comparator). The clinical variables were age, body mass index, type of infertility and smoking. Regarding treatment, antral follicle count; follicles >14 mm; oocytes in metaphase I and II; number of embryos; days of treatment; total dose of medication, chemical and clinical pregnancy rate and delivery after 1st embryo transfer. Absolute and relative frequencies were used for the qualitative variables; means, medians and t-test for the quantitative ones. Association between qualitative variables used the Chi-square test and, for quantitative variables, the Mann-Whitney test (p<0.05). The statistical program used was Stata 16.0.

RESULTS:

Among 407 medical records, 351 were included (combined oral contraceptive=243 and comparator=108). The combined oral contraceptive and the comparator groups had, respectively, mean (SD±) age 38.2 (4.5) and 38.2 (4.5) years; chemical pregnancy rates of 30.5% and 29.6% (p=0.281); clinical pregnancy rates of 24.8% and 24.1% (p=0.313) and abortion, 5% and 4.6% (p=0.544). The median time on combined oral contraceptives was 6 years.

CONCLUSIONS:

Previous use of combined oral contraceptives did not impact reproductive results in relation to the comparator group in patients undergoing assisted reproduction techniques in protocols with oral progestin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil