CEUS compared with CECT, MRI, and FDG-PET/CT for diagnosing CRC liver metastases: a diagnostic test accuracy systematic review and meta-analysis.
Expert Rev Gastroenterol Hepatol
; 18(9): 541-549, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39315472
ABSTRACT
OBJECTIVE:
To determine the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) compared with contrast-enhanced computed tomography (CECT), magnetic resonance imaging (MRI), and Fluorine-18-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for diagnosing suspected liver metastases in patients with newly diagnosed colorectal cancer (CRC).METHODS:
The meta-analysis using the bivariate model included studies on patients with newly diagnosed CRC only and excluded patients with non-CRC liver metastases, known liver metastases, patients treated with chemotherapy and local treatments, e.g. hepatic resection or radiofrequency ablation. We used QUADAS-2 to assess the methodological quality of the studies.RESULTS:
We included 32 studies, 6 studies evaluated the accuracy of CEUS (n = 937 participants), 26 studies evaluated CECT (n = 2,582), 8 studies evaluated MRI (n = 564) and 6 studies evaluated FDG-PET/CT (n = 813). Sensitivity FDG-PET/CT 94.4% [95% CI 90.7-98.1%], MRI 92.9% [95% CI 88.8-97.0%], CEUS 86.1% [95% CI 78.0-94.3%] and CECT 84.6% [95% CI 79.3-89.9%]. Specificity FDG-PET/CT 97.9% [95% CI 95.9-99.9%], CEUS 96.1% [95% CI 93.6-98.6%], MRI 94.4% [95% CI 90.5-98.3%], and CECT 94.3% [95% CI 91.8-96.8%].CONCLUSION:
FDG-PET/CT had significantly higher sensitivity and specificity than CECT, and significantly higher sensitivity than CEUS. MRI had a significantly higher sensitivity than CEUS, but a lower non-significant specificity. CECT had the lowest sensitivity and specificity. PROSPERO REGISTRATION DETAILS CRD42017055015 and CRD42017082996.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Neoplasias Colorretais
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Tomografia Computadorizada por Raios X
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Valor Preditivo dos Testes
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Ultrassonografia
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Meios de Contraste
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Compostos Radiofarmacêuticos
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Fluordesoxiglucose F18
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Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
/
Neoplasias Hepáticas
Limite:
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Expert Rev Gastroenterol Hepatol
/
Expert rev. gastroenterol. hepatol
/
Expert review of gastroenterology & hepatology.
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Dinamarca
País de publicação:
Reino Unido