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Ibrutinib-Related Uveitis in Non-Hodgkin Lymphoma Patients: A Case Report and Literature Review.
Mendez, Rafael; Pineda-Sierra, Juan Sebastián; Romero-Santos, Sofia; Cifuentes-González, Carlos; Bonaccorso, Silvina; Couto, Cristobal; Schlaen, Ariel; Mejía-Salgado, Germán; de-la-Torre, Alejandra.
Afiliação
  • Mendez R; Ophthalmology Department, Hospital Universitario San Ignacio, Facultad de Medicina, Pontificia Universidad Javeriana, Bogota, Colombia.
  • Pineda-Sierra JS; Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
  • Romero-Santos S; Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
  • Cifuentes-González C; Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
  • Bonaccorso S; Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
  • Couto C; Hematology Department, Hospital de Clínicas José de San Martín, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
  • Schlaen A; Uveitis Section, Ophthalmology Department, Hospital de Clínicas José de San Martín, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
  • Mejía-Salgado G; Uveitis Section, Ophthalmology Department, Hospital de Clínicas José de San Martín, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
  • de-la-Torre A; Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
Ocul Immunol Inflamm ; 32(8): 1882-1887, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39316714
ABSTRACT

PURPOSE:

To report two cases of ibrutinib-related uveitis and review the literature to date.

METHODS:

We report two cases of ibrutinib-related uveitis using CARE guidelines and review the cases reported in the literature.

RESULTS:

Case 1) A 55-year-old female with recurrent primary central nervous system lymphoma presented with bilateral decreased visual acuity, photophobia, and floaters that started one month after initiating oral treatment with ibrutinib. Chronic non-granulomatous bilateral anterior-intermediate uveitis with macular edema was identified. Secondary causes were ruled out, and a presumptive diagnosis of ibrutinib-related uveitis was made. Case 2) A 57-year-old female with Waldenström macroglobulinemia who was treated with ibrutinib for two years presented with bilateral blurred vision, photophobia, red eyes, and floaters. A diagnosis of non-granulomatous, noninfectious panuveitis with bilateral cystoid macular edema was made. Secondary causes were ruled out, and ibrutinib toxicity was the most likely cause.

CONCLUSION:

Ibrutinib-related uveitis is a novel and under-diagnosed clinical entity. The most frequent clinical presentation in the literature is bilateral, non-granulomatous, anterior, and intermediate uveitis. Macular edema is a frequent complication. Uveitis usually requires topical treatment and the suspension of ibrutinib. Switching to second-generation Bruton tyrosine kinase inhibitors is proposed as a potential therapeutic alternative.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Adenina Limite: Female / Humans / Middle aged Idioma: En Revista: Ocul Immunol Inflamm Assunto da revista: ALERGIA E IMUNOLOGIA / OFTALMOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Adenina Limite: Female / Humans / Middle aged Idioma: En Revista: Ocul Immunol Inflamm Assunto da revista: ALERGIA E IMUNOLOGIA / OFTALMOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido