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Comparative Study of the Anxiolytic Activity of Songorine in Elevated Plus Maze Test and by Recording Ultrasonic Vocalizations.
Nesterova, Yu V; Vsyakikh, O V; Kul'pin, P V; Povetyeva, T N; Zyuz'kov, G N; Suslov, N I; Zhdanov, V V; Losev, E A.
Afiliação
  • Nesterova YV; Laboratory of Phytopharmacology and Special Nutrition, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. nes-yuliya@yandex.ru.
  • Vsyakikh OV; Laboratory of Phytopharmacology and Special Nutrition, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Kul'pin PV; Laboratory of Phytopharmacology and Special Nutrition, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Povetyeva TN; Laboratory of Phytopharmacology and Special Nutrition, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Zyuz'kov GN; Laboratory of Phytopharmacology and Special Nutrition, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Suslov NI; Laboratory of Phytopharmacology and Special Nutrition, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Zhdanov VV; Laboratory of Phytopharmacology and Special Nutrition, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Losev EA; Laboratory of Phytopharmacology and Special Nutrition, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Bull Exp Biol Med ; 177(5): 648-652, 2024 Sep.
Article em En | MEDLINE | ID: mdl-39340623
ABSTRACT
It was found that the diterpene alkaloid songorine administered per os to mice at a dose of 25 µg/kg provides a pronounced anxiolytic effect during elevated plus maze testing comparable to the effect of the benzodiazepine anxiolytic phenazepam. Recording of ultrasonic vocalizations of animals revealed an increase in the number of short high-frequency (50 kHz) signals under the action of songorine and the reference drug, which confirms their anti-anxiety properties.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiolíticos / Vocalização Animal Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiolíticos / Vocalização Animal Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Estados Unidos