Pilot study on the effect of flavonoids on arterial stiffness and oxidative stress in chronic kidney disease.
World J Nephrol
; 13(3): 95262, 2024 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-39351188
ABSTRACT
BACKGROUND:
Flavonoids, the main class of polyphenols, exhibit antioxidant and antihypertensive properties.AIM:
To prospectively investigate the impact of flavonoids on arterial stiffness in patients with chronic kidney disease (CKD) stages I-IV.METHODS:
In this prospective, single-arm study, CKD patients with arterial hypertension and diabetes mellitus were enrolled. Baseline demographic, clinical, and laboratory variables were recorded. Patients received daily treatment with a phenol-rich dietary supplement for 3 months. Blood pressure, arterial stiffness (carotid-femoral pulse wave velocity, central pulse pressure), and oxidative stress markers (protein carbonyls, total phenolic compound, total antioxidant capacity) were measured at baseline and at study end.RESULTS:
Sixteen patients (mean age 62.5 years, 87.5% male) completed the study. Following intervention, peripheral systolic blood pressure decreased significantly by 14 mmHg (P < 0.001). Carotid-femoral pulse wave velocity decreased from 8.9 m/s (baseline) to 8.2 m/s (study end) (P < 0.001), and central pulse pressure improved from 59 mmHg to 48 mmHg (P = 0.003). Flavonoids also reduced oxidative stress markers including protein carbonyls (P < 0.001), total phenolic compound (P = 0.001), and total antioxidant capacity (P = 0.013).CONCLUSION:
Flavonoid supplementation in CKD patients shows promise in improving blood pressure, arterial stiffness, and oxidative stress markers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
World J Nephrol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Grécia
País de publicação:
Estados Unidos