Social network size, empathy, and white matter: A diffusion tensor imaging (DTI) study.

ABSTRACT

Social networks are fundamental for social interactions, with the social brain hypothesis positing that the size of the neocortex evolved to meet social demands. However, the role of fractional anisotropy (FA) in white matter (WM) tracts relevant to mentalizing, empathy, and social networks remains unclear. In this study, we investigated the relationships between FA in brain regions associated with social cognition (superior longitudinal fasciculus (SLF), cingulum (CING), uncinate fasciculus, inferior fronto-occipital fasciculus), social network characteristics (diversity, size, complexity), and empathy (cognitive, affective). We employed diffusion tensor imaging, tract-based spatial statistics, and mediation analyses to examine these associations. Our findings revealed that increased social network size was positively correlated with FA in the left SLF. Further, our mediation analysis showed that lower FA in left CING was associated with increased social network size, mediated by cognitive empathy. In summary, our findings suggest that WM tracts involved in social cognition play distinct roles in social network size and empathy, potentially implicating affective brain regions. In conclusion, our findings offer new perspectives on the cognitive mechanisms involved in understanding others' mental states and experiencing empathy within supportive social networks, with potential implications for understanding individual differences in social behavior and mental health.