Balancing immune activation with Itk.

Kaul, Zenia; Schwartzberg, Pamela L

Kaul, Zenia; Schwartzberg, Pamela L.

Afiliação

Kaul Z; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Schwartzberg PL; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: pamela.schwartzberg@nih.gov.

Trends Pharmacol Sci ; 2024 Oct 01.

Article em En | MEDLINE | ID: mdl-39358175

ABSTRACT

ABSTRACT

Development of protective immune responses relies on a balance between proinflammatory CD4 T helper (Th) cell populations such as Th17 cells and regulatory CD4 T cells (Tregs) that keep immune activation in check. Evidence that interleukin-2-inducible T cell kinase (Itk) regulates this balance supports therapeutic applications for Itk inhibition.

Palavras-chave

Ca(2+) signaling; Itk; Th17 cells; Tregs; cytokines

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Trends Pharmacol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

Texto completo

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PubMed Links

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